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My absolute favorite strain! Extremely uplifting, great for anxiety! I'm prone to paranoia and sensitive to THC in general, so I always tread carefully when it comes to sativa-dominant hybrids. However, Permafrost has consistently provided a wonderful clear-headed and euphoric high, without any paranoia whatsoever. The body high is subtle and I personally did not feel the pain relief was anything significant, but the giddy elated feeling I get from Permafrost is like no other. Would absolutely recommended for anyone with depression or anxiety, also good for socializing or creative work.